What is meant by immune tolerance?

Tolerance is the prevention of an immune response against a particular antigen. For instance, the immune system is generally tolerant of self-antigens, so it does not usually attack the body’s own cells, tissues, and organs.

What are examples of immunogens?

We can define an immunogen as a complete antigen which is composed of the macromolecular carrier and epitopes (determinants) that can induce immune response. An explicit example is a hapten. Haptens are low-molecular-weight compounds that may be bound by antibodies, but cannot elicit an immune response.

What is tolerogenic effect?

These tolerogenic effects are mostly mediated through regulation of T cells such as inducing T cell anergy, T cell apoptosis and induction of Tregs. Tolerogenic DCs present a potential strategy for treatment of autoimmune diseases, allergic diseases and transplant rejections.

What is a tolerogenic antigen?

Tolerogenic antigen-presenting cells (APCs) are attractive agents for the treatment of autoimmune and inflammatory diseases that are mediated, at least in part, by antigen-specific autoreactive T cells.

Is Immune Tolerance good or bad?

Immune tolerance is important for normal physiology. Central tolerance is the main way the immune system learns to discriminate self from non-self. Peripheral tolerance is key to preventing over-reactivity of the immune system to various environmental entities (allergens, gut microbes, etc.).

What happens if immune tolerance is lost?

6 Immune tolerance If immunological self-tolerance is lost, the body develops an autoimmunity against its own tissues and cells, which become the source of the autoimmune disease. Self-tolerance plays a key role in the prevention and treatment of immune disorder diseases, especially autoimmune diseases.

What is a tolerogenic immune response?

Tolerogenic therapies employ the inbuilt tolerance mechanisms of a class of immune cells called dendritic cells. Dendritic cells are divided into two main subsets: Mature dendritic cells are immunogenic. Their physiological role is to bridge innate and adaptive immune responses by presenting antigens to T-lymphocytes.

Why do we need immune tolerance?