Can cyclophosphamide cause bladder problems?

The urinary bladder complications that have been reported with the use of cyclophosphamide include acute hemorrhagic cystitis, chronic cystitis, urine cytologic abnormalities, mucosal telangiectasia, interstitial fibrosis, and transitional cell carcinoma.

What cancer is Cytoxan used for?

Cyclophosphamide is used alone or in combination with other medications to treat Hodgkin’s lymphoma (Hodgkin’s disease) and non-Hodgkin’s lymphoma (types of cancer that begin in a type of white blood cells that normally fights infection); cutaneous T-cell lymphoma (CTCL, a group of cancers of the immune system that …

What are the long-term side effects of Cytoxan?

The long-term side effects of cyclophosphamide (Cytoxan) are damage to the bladder and the bone marrow. Bladder cancer is a well-known risk and continues to arise at least 10-15 years after the drug was given.

Can chemo cause bladder cancer?

Chemotherapy and radiation therapy: Long-term use of the chemotherapy drug cyclophosphamide is associated with an increased risk of bladder cancer. Drinking extra fluids while taking this drug can help lower this risk. Radiation aimed at the pelvis is also considered a risk factor for bladder cancer.

When do Cytoxan side effects start?

Nausea and vomiting: more common with larger doses, usually beginning 6-10 hours after therapy.

How long does Cytoxan stay in your body?

When cyclophosphamide is given intravenously, the white blood cell count tends to reach its low point (“nadir”) between 7 and 14 days after administration.

Does Cytoxan cause weight gain?

For example, unlike prednisone, cyclophosphamide is NOT associated with the weight gain, bone thinning, increased blood pressure, or a tendency to induce diabetes.

How can I reduce the side effects of Cytoxan?

Nausea and vomiting can be severe. In some cases, drug therapy may be necessary to prevent or relieve nausea and vomiting. Changes in diet such as eating several small meals or limiting activity may help lessen some of these effects. If these effects persist or worsen, notify your doctor or pharmacist promptly.

How quickly does Cytoxan work?

Like all DMARDs, it takes time to work. Its positive effects will likely start at 4-8 weeks.

What are the Common side effects of Cytoxan?

If experienced, these tend to have a Severe expression. Anemia. Decreased Blood Platelets. Increased Uric Acid Due To Cancer Chemotherapy. Inflammation Of The Bladder With Hemorrhage. Kidney Damage. Syndrome Of Inappropriate Antidiuretic Hormone Secretion. Yellowing Of Skin Or Eyes From Liver Problems.

What kind of cancer is Cytoxan used for?

What Is Cytoxan? Cytoxan (cyclophosphamide) is a cancer ( chemotherapy) medication used to treat several types of cancer. Cytoxan is also used to treat certain cases of nephrotic syndrome (kidney disease) in children.

Are there any side effects to taking cyclophosphamide?

The following are less common side effects (occurring in 10-29%) for patients receiving cyclophosphamide: Loss of fertility: Your ability to conceive or father a child may be affected by cyclophosphamide. Diarrhea Mouth sores Bladder irritation and bleeding (hemorrhagic cystitis) (see bladder problems)

Is it safe to take Cytoxan during pregnancy?

Cytoxan is not recommended for use during pregnancy. It may cause harm to a fetus. Women of childbearing age and men should use birth control during treatment and for some period afterwards. This drug passes into breast milk. Because of the potential risk to the infant, breastfeeding while using this drug is not recommended.