Anion gap (AG) 15. How do you calculate anion gap? For practical purposes anion gap is calculated using only Sodium, Chlorides and Total CO2.
Why does anion gap increase in acidosis?
As bicarbonate is consumed in buffering the protons (hydrogen cation) of the acid, the anion of the acid accumulates, thereby preserving electrochemical neutrality. Since the accumulating anion is “unmeasured”, the anion gap increases. Accumulation of lactic acid is probably the most common cause of metabolic acidosis.
Why does Hypoalbuminemia cause low anion gap?
A low anion gap is frequently caused by hypoalbuminemia. Albumin is a negatively charged protein and its loss from the serum results in the retention of other negatively charged ions such as chloride and bicarbonate.
What can cause anion gap to be low?
The most common causes of low anion gap results may include the following.
Laboratory error. If your test indicates a low anion gap value, your doctor may order a second test to account for laboratory error.
Monoclonal and polyclonal gammopathy.
What does anion gap mean in blood work?
The anion gap blood test is used to show whether your blood has an imbalance of electrolytes or too much or not enough acid. Too much acid in the blood is called acidosis. If your blood does not have enough acid, you may have a condition called alkalosis.
What is CO2 normal range?
The normal range is 23 to 29 milliequivalents per liter (mEq/L) or 23 to 29 millimoles per liter (mmol/L). Normal value ranges may vary slightly among different laboratories.
What was the anion gap on my Bloodwork?
Everything was good, except the “anion gap” which was VERY low at 3.7; reference range is 7-16. I pulled my older bloodwork and it was always fine. The only other thing that is off is my CO2 is 35 (reference range 22-29).
What causes normal anion gap in metabolic acidosis?
Normal anion gap metabolic acidosis is also called hyperchloremic acidosis because the kidneys reabsorb chloride (Cl −) instead of reabsorbing HCO 3−. Many GI secretions are rich in HCO 3− (eg, biliary, pancreatic, and intestinal fluids); loss due to diarrhea, tube drainage, or fistulas can cause acidosis.
How are acids and bases related to anion gap?
Electrolytes are electrically charged minerals that help control the balance of chemicals in your body called acids and bases. Some of these minerals have a positive electric charge. Others have a negative electric charge. The anion gap is a measurement of the difference-or gap-between the negatively charged and positively charged electrolytes.