The cause of alternating hemiplegia of childhood is the mutation of ATP1A3 gene. In a study of fifteen females and nine males’ patient with alternating hemiplegia, a mutation in ATP1A3 gene was present.
What is an alternating hemiplegia?
Definition. Alternating hemiplegia is a rare neurological disorder that develops in childhood, most often before the child is 18 months old. The disorder is characterized by recurrent episodes of paralysis that involve one or both sides of the body, multiple limbs, or a single limb.
What is Weber’s syndrome?
Weber syndrome, classically described as a midbrain stroke syndrome and superior alternating hemiplegia, involves oculomotor fascicles in the interpeduncular cisterns and cerebral peduncle, thereby causing ipsilateral third nerve palsy with contralateral hemiparesis.
What is uncrossed hemiplegia?
Lesions above the level of the brainstem result in uncrossed hemiplegia. For example, a lesion in the left internal capsule would result in right hemiplegia and right facial weakness of the upper motor neuron type.
What is the difference between hemiparesis and hemiplegia?
Hemiparesis is a mild or partial weakness or loss of strength on one side of the body. Hemiplegia is a severe or complete loss of strength or paralysis on one side of the body. The difference between the two conditions primarily lies in severity.
How is Weber’s syndrome diagnosed?
How Is Sturge-Weber Syndrome Diagnosed?
an eye exam, usually done by an ophthalmologist. ophthalmologist.
magnetic resonance imaging (MRI) scans.
Which artery is damaged by Weber Syndrome?
Weber syndrome occurs with an occlusion of the median and/or paramedian perforating branches of the basilar artery. Typical clinical findings include ipsilateral CN III palsy, ptosis, and mydriasis (ie, damage to parasympathetic fibers of CN III) with contralateral hemiplegia.
Is there sensory loss in hemiplegia?
Clinical Features. Hemiplegia is an essential feature. Associated features may include visual disturbance, sensory loss, such as numbness or paresthesias of the face or a limb, and difficulty with speech.
Is there a diagnostic test for alternating hemiplegia?
There is no diagnostic test for alternating hemiplegia, which makes it very difficult to diagnose. Also, because alternating hemiplegia is extremely rare, it is frequently missed and the patient is often misdiagnosed.
What happens to a child with alternating hemiplegia?
Many children affected by alternating hemiplegia also suffer from epilepsy. Seizures may occur during an attack but more often occur between attacks. Anti-epilepsy drugs are given to prevent or lessen the seizures, but the drugs often don’t work and have severe side effects that require the patient to discontinue use.
How is flunarizine used to treat alternating hemiplegia?
Flunarizine, which blocks calcium channels, is an antiepilepsy drugs used in 50% of patients, and has been shown to shorten the duration of attacks as well as reducing the severity of the attacks. While Flunarizine does not stop the attacks, it is most common drug prescribed to treat those suffering from alternating hemiplegia.
What are the different types of treatment for hemiplegia?
Medical treatment of hemiplegia can be separate into several different categories: sleep as a management technique. Seizure trigger include exposure to cold, emotional stress, fatigue, bathing, hyperthermia/hypothermia, and upper respiratory infection.