What drugs are contraindicated with G6PD deficiency?

Which medications should be avoided in patients with G6PD deficiency-related hemolytic anemia?

Acetanilid.
Furazolidone.
Isobutyl nitrite.
Nalidixic acid.
Naphthalene.
Niridazole.
Sulfa drugs.

What drugs are used to treat patients with G6PD deficiency?

Sulfonamides and Sulfones:

Dapsone.
Furosemide (Lasix)
Sulfacetamide (Sulamyd)
Sulfamethoxazole (Bactrim, Septra)
Sulfanilamide.
Sulfasalazine (Azulfidine)
Sulfisoxazole (Gantrisin)

Does aging affect G6PD test?

Age-Period-Cohort analysis showed no inflection points across age groups, especially after age 80. The effects of time period and birth cohorts on G6PD deficiency were negligible (frequencies before and after 1950 were 11.0% and 11.8%, respectively).

What is the most serious complication of G6PD?

Most have a mild to moderate anemia, but severe, transfusion-dependent anemia can develop. Affected individuals can potentially develop severe complications such as hypovolemic shock. In rare cases, severe acute hemolysis has led to acute kidney failure.

How do you get rid of G6PD?

There is no cure for G6PD deficiency, and it is a lifelong condition. However, most people with G6PD deficiency have a completely normal life as long as they avoid the triggers.

What are the side effects of G6PD deficiency?

Most individuals with G6PD deficiency are asymptomatic throughout life. Symptoms of acute hemolysis associated with G6PD deficiency include anemia, fatigue, back or abdominal pain, jaundice, and hemoglobinuria. The most common precipitators of oxidative stress and hemolysis in G6PD deficiency include medication use and infection.

When to consider G6PD deficiency in hemolysis patients?

G6PD deficiency should be considered in patients who experience acute hemolysis after exposure to known oxidative medications, infection, or ingestion of fava beans. A diagnosis of G6PD deficiency is most often made through enzymatic activity detection, but molecular analysis may be required in fema …

When to consider glucose-6 phosphate dehydrogenase deficiency?

Review and drug therapy implications of glucose-6-phosphate dehydrogenase deficiency G6PD deficiency should be considered in patients who experience acute hemolysis after exposure to known oxidative medications, infection, or ingestion of fava beans.

How does aging affect the metabolism of drugs?

The impact of aging has a variable effect on phase II metabolic pathways ( 14 ). Drug metabolism by glucuronidation (involving UDP-glucuronosyltransferases [UGT]) appears to be preserved in otherwise fit and well older people. A study by Court ( 19) investigated the variability in UGT metabolic activity using a human liver bank.