Alternative name: Description: Myeloperoxidase is the most commonly recognised p-ANCA antigen. It is a 140kDa cationic protein found predominantly in azurophilic granules of neutrophils and monocytes.
What is an antibody IHC?
Immunohistochemistry (IHC) uses antibodies to detect the location of proteins and other antigens in tissue sections. The antibody-antigen interaction is visualized using either chromogenic detection with a colored enzyme substrate, or fluorescent detection with a fluorescent dye.
What is MPO a marker for?
Myeloperoxidase (MPO): inflammation marker that can serve as cardiac marker.
What causes high MPO?
Elevated levels of circulating MPO are observed in patients with coronary artery diseases, unstable angina, and acute myocardial infarction [8,136,137,138]. Plasma MPO concentration was reported to be higher in myocardial infarction (MI) patients (55 ng/mL) as compared to control subjects (39 mg/mL) .
Why is IHC useful?
Immunohistochemistry (IHC) is an important application of monoclonal as well as polyclonal antibodies to determine the tissue distribution of an antigen of interest in health and disease. IHC is widely used for diagnosis of cancers; specific tumor antigens are expressed de novo or up-regulated in certain cancers.
Why is IHC test done?
IHC, or ImmunoHistoChemistry, is a special staining process performed on fresh or frozen breast cancer tissue removed during biopsy. IHC is used to show whether or not the cancer cells have HER2 receptors and/or hormone receptors on their surface. This information plays a critical role in treatment planning.
How do I lower my MPO?
Adopting a heart-healthy diet can help to lower your Lp-PLA2 levels. Eat more vegetables, fruits, and whole grain foods and reduce the amount of fatty foods you eat. Exercise can also help to reduce your Lp-PLA2 levels. If you smoke, quit.
How do I lower my MPO level?
What does IHC positive mean?
A positive test result means that the laboratory found a particular change in the proteins of your tumor. This means that it is possible that you have an inherited genetic condition and further genetic testing is recommended.
Why IHC test is done after biopsy?
Where can I find anti myeloperoxidase ( MPO ) antibodies?
244 Myeloperoxidase (MPO) Antibodies from 23 manufacturers are available on www.antibodies-online.com. Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules.
How is pa5-16672 used in IHC ( P ) applications?
PA5-16672 targets Myeloperoxidase in IHC (P) applications and shows reactivity with Human, mouse, and Rat samples. The PA5-16672 immunogen is purified human granulocytic MPO. PA5-16672 detects MPO-DNA complexes in purified PMA-induced human neutrophil extracellular traps in ELISA application.
How does mouse MPO work to kill microbes?
MPO is released upon activation to catalyze the formation of powerful oxidants such as hypochlorous acid, which kills microbes. Unprocessed pro-MPO can also be released. Mouse MPO shares 87% amino acid sequence identity with that of human MPO. R&D Systems personnel manually curate a database that contains references using R&D Systems products.
Which is a disulfide-linked heterodimer in MPO?
MPO is synthesized as a preproprotein that undergoes proteolytic processing to generate a disulfide-linked heterodimer of the N-terminal beta -subunit (12 kDa) and C-terminal alpha subunit (60 kDa). Active MPO is a tetramer of two beta -subunits and two alpha -subunits that are also disulfide-linked through the two alpha -subunits.