Where is hyaluronidase found in the body?

Human hyaluronidase is present both in organs (testis, spleen, skin, eyes, liver, kidneys, uterus, and placenta) and in body fluids (tears, blood, and semen) [5]. There are six known types (hyaluronidase 1–4, PH-20, and HYALP1).

What is the role of hyaluronidase?

Hyaluronidases, a family of enzymes that are able to degrade hyaluronic acid (HA), are employed in medicine to increase drug diffusion and reverse the effects of HA filler injections. Hyaluronidases are able to dissolve subcutaneous nodules or to correct excessive quantities of injected filler.

What is the role of hyaluronidase in pathogenesis?

Many pathogenic bacteria able to establish infections at the mucosal or skin surface produce the enzyme hyaluronidase. The role of providing nutrients for the cell may be the main function of hyaluronidases in Gram-negative organisms [24].

Where does hyaluronidase come from?

Hyaluronidase is a natural substance found in the body, which is collected from either cows or pigs. It is cleaned up to remove animal substances. It may also be produced in a laboratory that recreates it from human albumin sources.

How long does hyaluronidase stay in your system?

Hyaluronidase has immediate effect and a half-life of two minutes with duration of action of 24 to 48 hours. Once we start the process of injecting the hyaluronidase, the dermal filler in that area starts to break down and soften immediately.

Does hyaluronidase dissolve your own tissue?

Hyaluronidase does not dissolve your own tissue. Though Hyaluronidase can dissolve your body’s own natural hyaluronic acid, hyaluronidase is not able to dissolve tissue.

Can you use too much hyaluronidase?

RISKS OF HYALURONIDASE: Unless there is a past medical history of allergic reaction or anaphylaxis to hyaluronidase or insect bites, previous history of allergy seems unrelated for the administration of hyaluronidase and it can be safely performed. Just like overfilling can happen with filler, so can over dissolving.

Does filler ever go away?

Most of the time, HA based fillers (Juvederm, Restylane ) last anywhere from 6 to 18 months. In some individuals, they last a bit shorter or longer. Some other fillers such as Sculptra can last 2 years, but usually that is not a first choice for lip augmentation.

How are hyaluronidases used in the treatment of complications?

How are hyaluronidases eliminated from the human body?

After intravenous administration, hyaluronidases undergo elimination through the kidneys with a known clearance (t 1/2 = 2.1 ± 0.2 min), where t 1/2 is half-time. Nevertheless, the mechanism of inactivation inside the dermis and other tissues is still unknown, mainly depending on HA synthesis.

How does hyaluronidase decrease the viscosity of ha?

Hyaluronidases are endoglycosidases that depolymerize HA, producing multiple effects in tissues: they decrease the normal high viscosity of HA, lessening its lubricating quality and acting as a “spreading factor” facilitating the diffusion of several substances injected subcutaneously, like dyes and antiviral vaccines. 6

How are hyaluronidases a group of glycosidases?

Hyaluronidases represent a group of glycosidases, which mainly degrade hyaluronan, a linear, non-sulfated polysaccharide composed of repeating disaccharide units [D-glucuronic acid (1-β-3) N-acetyl-D-glucosamine (1-β-4)]n. They are widely distributed in nature, being found in mammals, insects, leeches and bacteria.